Objective: To identify brain regions whose metabolic impairment contributes to dementia with Lewy bodies (DLB) clin-ical core features expression and to assess the influence of severity of global cognitive impairment on the DLB hypo-metabolic pattern.
Methods: Brain fluorodeoxyglucose positron emission tomography and information on core features were available in171 patients belonging to the imaging repository of the European DLB Consortium. Principal component analysis was applied to identify brain regions relevant to the local data variance. A linear regression model was applied to generate core-feature–specific patterns controlling for the main confounding variables (Mini-Mental State Examination [MMSE],age, education, gender, and center). Regression analysis to the locally normalized intensities was performed to generate an MMSE-sensitive map.
Results: Parkinsonism negatively covaried with bilateral parietal, precuneus, and anterior cingulate metabolism; visual hallucinations (VH) with bilateral dorsolateral–frontal cortex, posterior cingulate, and parietal metabolism; and rapid eye movement sleep behavior disorder (RBD) with bilateral parieto-occipital cortex, precuneus, and ventrolateral–frontal
Authors: Morbelli, S; Chincarini, A; Brendel, M; Rominger, A; Bruffaerts, R; Vandenberghe, R; Kramberger, MG; Trost, M; Garibotto, V; Nicastro, N; Frisoni, GB; Lemstra, AW; van der Zande, J; Pilotto, A; Padovani, A; Garcia-Ptacek, S; Savitcheva, I; Ochoa-Figueroa, MA; Davidsson, A; Camacho, V; Peira, E; Arnaldi, D; Bauckneht, M; Pardini, M; Sambuceti, G; Aarsland, D; Nobili, F
Published paper: Morbelli, S; Chincarini, A; Brendel, M; Rominger, A; Bruffaerts, R; Vandenberghe, R; Kramberger, MG; Trost, M; Garibotto, V; Nicastro, N; Frisoni, GB; Lemstra, AW; van der Zande, J; Pilotto, A; Padovani, A; Garcia-Ptacek, S; Savitcheva, I; Ochoa-Figueroa, MA; Davidsson, A; Camacho, V; Peira, E; Arnaldi, D; Bauckneht, M; Pardini, M; Sambuceti, G; Aarsland, D; Nobili, F, Metabolic patterns across core features in dementia with lewy bodies, ANN NEUROL,715-725,2019,10.1002/ana.25453