{"id":12792,"date":"2023-01-18T10:54:43","date_gmt":"2023-01-18T09:54:43","guid":{"rendered":"https:\/\/www.pi.infn.it\/?p=12792"},"modified":"2023-01-18T17:02:56","modified_gmt":"2023-01-18T16:02:56","slug":"positron-emission-tomography-for-real-time-verification-during-particle-therapy-di-peter-dendooven-partrec-university-medical-center-groningen","status":"publish","type":"post","link":"https:\/\/www.pi.infn.it\/?p=12792","title":{"rendered":"Positron Emission Tomography for real-time verification during particle therapy di Peter Dendooven (PARTREC, University Medical Center Groningen)"},"content":{"rendered":"\n

Lunedi 23 gennaio 23 ore 15:00<\/span>

Abstract:
<\/strong>In comparison to photon radiotherapy, particle<\/span> beam radiotherapy<\/span> (mostly protons and <\/span>carbon ions are used)<\/span> results in a lower radiation dose to normal tissue, reducing long<\/span>– <\/span>term complications and increasing the quality of life of patients. However, the dos<\/span>e <\/span>distribution<\/span> delivered during<\/span> particle<\/span> therapy<\/span> is quite sensitive to anatomical changes in <\/span>the patient,<\/span> particle<\/span> range uncertainties and<\/span> patient setup<\/span> errors.<\/span> Because of this, s<\/span>everal <\/span>techniques for in<\/span>–<\/span>vivo dose delivery verification have and are being developed.<\/span> The most <\/span>investigated method is positron emission tomography (PET) of the positron emitters that <\/span>are created by the particles via nuclear reactions in the patient. The P<\/span>ET signal is <\/span>obviously delayed by the radioactive decay half<\/span>–<\/span>life. For most positron emitters this <\/span>precludes real<\/span>–<\/span>time feedback and leaves room for biological washout. <\/span>I will report on investigations towards real<\/span>–<\/span>time verification using PET during proton, <\/span>helium ion and heavy ion therapy. At the University Medical Center Groningen, w<\/span>e are <\/span>investigatin<\/span>g<\/span> imaging<\/span> of<\/span> 12<\/span> N<\/span>, with a half<\/span>–<\/span>life of just 11<\/span> ms,<\/span> produced by the proton<\/span> or <\/span>helium<\/span> beam in the patient. I will report on recent<\/span> proof<\/span>–<\/span>of<\/span>–<\/span>principle demonstratio<\/span>ns<\/span> of <\/span>the range accuracy in homogeneous targets, and discuss our present research to<\/span>
establish the clinical relevance on the basis of irradiations of an anthropomorphic head <\/span>phantom.<\/span> Treatment with positron emitting radioactive<\/span> heavy ions<\/span> gives a much stro<\/span>nger <\/span>PET signal which is more closely correlated to the Bragg peak compared to<\/span> treatment <\/span>with<\/span> stable heavy ions. Within the BARB project at the GSI Helmholtzzentrum<\/span> f\u00fcr <\/span>Schwerionenforschun<\/span>g<\/span>, we have investigated the precision with which the range of<\/span> 10,11<\/span> C <\/span>and<\/span> 14,15<\/span> O can be measured<\/span> using PET<\/span>. The design and outcome of these experiments <\/span>will be discussed.

Il seminario si terr\u00e0 in presenza nella sala Galilei (131) e via zoom al seguente indirizzo: https:\/\/infn-it.zoom.us\/j\/84261721878?pwd=MDZNaGdBUlcvUUJXa2phSHZVZk5sdz09<\/a><\/strong>
<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Lunedi 23 gennaio 23 ore 15:00 Abstract:In comparison to photon radiotherapy, particle beam radiotherapy (mostly protons and carbon ions are used) results in a lower radiation dose to normal tissue, reducing long– term complications and increasing the quality of life of patients. However, the dose distribution delivered during particle therapy is quite sensitive to anatomical […]<\/p>\n","protected":false},"author":15,"featured_media":12793,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[8],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-13 23:04:52","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=\/wp\/v2\/posts\/12792"}],"collection":[{"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12792"}],"version-history":[{"count":5,"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=\/wp\/v2\/posts\/12792\/revisions"}],"predecessor-version":[{"id":12816,"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=\/wp\/v2\/posts\/12792\/revisions\/12816"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=\/wp\/v2\/media\/12793"}],"wp:attachment":[{"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12792"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12792"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pi.infn.it\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12792"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}